#Formation of Regulatory Patterns During Signal Propagation in a Mammalian Cellular Network:
#Avi Maayan, Sherry L. Jenkins, Susana Neves, Anthony Hasseldine, Elizabeth Grace, Benjamin Dubin-Thaler, Narat J. Eungdamrong, Gehzi Weng, Prahlad T. Ram, J. Jeremy Rice, Aaron Kershenbaum, Gustavo A. Stolovitzky, Robert D. Blitzer, and Ravi Iyengar Science 12 August 2005 309: 1078-1083 [DOI: 10.1126/science.1108876]
MSK2 -> HistoneH3
MSK1 -> HMG14
MSK2 -> HMG14
EPHRIN -> EPHB2
EPHB2 -> KALIRIN
EPHB2 -> SYNDECAN
KALIRIN -> RAC
DOC2 -> MUNC13
CALCIUM -> DOC2
PIP2 -> DOC2
CALCIUM -> DOC2
DOC2 -> MUNC13
CALCIUM -> DOC2
DOC2 -> MUNC13
DOC2 -> MUNC13
HRS2 -| SNAP25
PKC -| EGFR
MEK5 -> ERK5
KChIP4 -> KV42
KV43 -> POTASSIUM
KV42 -> POTASSIUM
PKCZETA -> IKKB
PKCZETA -> MEK5
SEQUESTOSOME -> PKCZETA
MEKK1 -| IKBA
MEKK1 -> IKKA
TRADD -> TRAF2
TRADD -> FADD
NIK -> IKKA
NIK -> IKKB
NIK -> IKKB
IKKB -| IKBA
IKKA -| IKBA
RIP -> SEQUESTOSOME
TRADD -> RIP
TNIK -| GELSOLIN
TRADD -> TRAF2
TNFR1 -> TRADD
TNFR1 -> MADD
TNFALPHA -> TNFR1
CASPASE3 -| PTEN
ABL -> DELTA_CATENIN
NCADHERIN -> DELTA_CATENIN
DELTA_CATENIN -> CORTACTIN
DELTA_CATENIN -> SPHK
PP1 -| RCS
PP2A -| RCS
PKA -> RCS
RCS -| CALMODULIN
GLYCINE -> NMDAR
GLYCINE -> NMDAR
GLYCINE -> NMDAR
CAMKII -| SYNAPSIN
CAMKII -| SYNAPSIN
CAMKII -> MAP2
CAMKII -> MAP2
GLYT1 -| GLYCINE
GLYT1 -| GLYCINE
GLYT1 -| GLYCINE
CAMKII -> AMPAR
CAMKII -> AMPAR
CALCIUM -> CALMODULIN
CASPASE3 -| ICAD
ICAD -| CAD
CASPASE3 -| ICAD
ICAD -| CAD
PDK1 -> S6K
S6K -> CFOS
FRK -> CFOS
GLUTAMATE -> AMPAR
GIRK -> POTASSIUM
PIP2 -> GIRK
GBETAGAMMA -> GIRK
GBETAGAMMA -> GIRK
SODIUM -> GIRK
AMPAR -> SODIUM
AMPAR -> SODIUM
GABA -| GABABR
TRKA -> SHC
TRKA -> SHC
TRKA -> SHC
CALMODULIN -> CAMKII
TRKA -> GRIT
TRKA -> CRK
TRKA -> CRK
CRK -> GRIT
JNK -> CJUN
CASPASE9 -> CASPASE6
CASPASE9 -> CASPASE6
CASPASE9 -> CASPASE3
CASPASE9 -> CASPASE7
ATF2 -> CJUN
ATF2 -> CRE
ATF2 -> TRE
VRK1 -> ATF2
MGLUR1 -> GBETAGAMMA
MGLUR1 -> GALPHAQ
MGLUR5 -> GBETAGAMMA
MGLUR5 -> GBETAGAMMA
MGLUR5 -> GALPHAQ
MGLUR5 -> GALPHAQ
GLUTAMATE -> NMDAR
GLYCINE -> NMDAR
CALMODULIN -> IQGAP
CALMODULIN -> IQGAP
IQGAP -| RAS
INTEGRIN -> ILK
TCF -> LEF1
LEF1 -> MITF
GSK3 -> MITF
NGF -> TRKA
NGF -> TRKA
NGF -> TRKA
TRKA -> PLCGAMMA
APS -> VAV
LCK -> VAV
GRB2 -> SOS
GRB2 -> SOS
SOS -> RAS
SOS -> RAS
SOS -> RAS
IRS1 -> PI3K
PI3K -> PIP3
PI3K -| PIP2
PIP3 -> PDK1
PDK1 -> PKB
PKA -| BAD
RSK -| BAD
P1433 -| BAD
RIM -> RABPHILIN
RIM -> P1433
RIM -> RAB3
RIM -> RAB3
RIM -> MUNC13
RIM -> SYNAPTOTAGMIN
RIM -> SNAP25
CAMPGEFII -> RIM
CAMP -> CAMPGEFII
BAD -> BCLXL
BAD -> BCLXL
CREB -> ATF1
PKA -> ATF1
PKA -> CREB
PKA -> CREB
MAPK -> RSK
MEK1 -> MAPK
MEK1 -> MAPK
RAF1 -> MEK1
PLA2 -> AA
PLA2 -> AA
AA -> PKC
AA -> PKC
PIP3 -> PKB
PIP2 -> PKB
PIP2 -> PMCA
PIP2 -> PMCA
PMCA -| CALCIUM
CALMODULIN -> PMCA
CAMP -> PKA
CREB -> CRE
DAG -> PKC
CALCIUM -> PKC
FIVEHT1AR -> GALPHAI
GALPHAQ -> PLCBETA
GALPHAQ -> PLCBETA
GALPHAQ -> PLCBETA
RSK -> CREB
MAPK -> MAPKAPK2
PKA -| SYNAPSIN
CAMKI -| SYNAPSIN
CAMKII -| SYNAPSIN
MAPK -| SYNAPSIN
MAPK -| SYNAPSIN
CALCIUM -> SYNAPSIN
VAV -> RAC
CAMKII -> TIAM1
TIAM1 -> RAC
GRB2 -> VAV
ZAP70 -> VAV
SRC -> VAV
SRC -> VAV
RASGRP3 -> RAS
RASGRP3 -> RAP1
PKC -> RASGRP3
RAS -> RALGDS
RAP1 -> RALGDS
RALGDS -> RAL
NOS -> NO
NOS -> NO
CALMODULIN -> NOS
CALMODULIN -> NOS
RAC -> PAK
CDC42 -> PAK
CALCIUM -> DREAM
DREAM -| DRE
CREM -| DREAM
DREAM -| CREB
MSK1 -> CREB
P38 -> MSK1
MAPK -> MSK1
S6K -> CREM
P38 -> MAPKAPK2
P38 -> MAPKAPK2
MAPK -> MAPKAPK2
NCK -> PAK
NCK -> PAK
NCK -> PAK
NCK -> PAK
MEK6 -> P38
P38 -> MNK1
MAPK -> MNK1
P38 -> MNK1
MAPK -> MNK1
MNK1 -> EIF4E
MNK1 -> EIF4E
TCF -> SRF
ELK1 -> SRE
MAPK -> ELK1
MAPK -> ELK1
CBP -> CJUN
CBP -> ELK1
CBP -| TCF
CALMODULIN -> CAMKIV
CALMODULIN -> AC1
CALMODULIN -> AC1
CALMODULIN -> AC1
CALMODULIN -> CALCINEURIN
GBETAGAMMA -> PLCBETA
GBETAGAMMA -> PLCBETA
GBETAGAMMA -> PLCBETA
GBETAGAMMA -> PLCBETA
GBETAGAMMA -> PLCBETA
GALPHAQ -> PLCBETA
CAMKIV -> CREB
CAMKIV -> CREB
NMDAR -> CALCIUM
ACH -> M2R
ACH -> M2R
ACH -> M2R
M2R -> GALPHAI
M2R -> GALPHAI
M2R -> GALPHAI
M2R -> GBETAGAMMA
M2R -> GBETAGAMMA
GBETAGAMMA -> RASGAP
GBETAGAMMA -> bARK
GBETAGAMMA -> AC2
GBETAGAMMA -> AC2
GBETAGAMMA -> bARK
GBETAGAMMA -> bARK
CALMODULIN -> NOS
BETACATENIN -> LEF
BETACATENIN -> LEF
RAS -> PI3K
RAS -> PI3K
RAS -> PI3K
GBETAGAMMA -> PI3K
BETACATENIN -> TCF
GBETAGAMMA -| NTYPECA
GBETAGAMMA -| NTYPECA
IRS1 -> GRB2
IRS1 -> GRB2
INSULIN -> IR
INSULIN -> IR
INSULIN -> IR
IRS1 -> PI3K
IRS1 -> NCK
IR -> IRS1
IR -> IRS1
PA -> SHP1
PIP3 -> SHP1
JAK -> STAT
JAK -> STAT
GBETAGAMMA -> IRS1
PIP2 -| bARK
PKC -| NMDAR
SSTR1 -> GALPHAI
SSTR1 -> GBETAGAMMA
SSTR1 -> GALPHAO
SS -> SSTR1
SS -> SSTR2
SS -> SSTR1
SS -> SSTR2
SSTR2 -> SHP1
D1R -> GALPHAS
D1R -> GALPHAI
SSTR2 -> GALPHAO
SSTR2 -> GALPHAI
SSTR2 -> GBETAGAMMA
PAF -> PAFR
PAF -> PAFR
PAF -> PAFR
PAF -> PAFR
FIVEHT2AR -> GALPHAQ
PAFR -> GALPHAO
PAFR -> GALPHAO
PAFR -> GALPHAQ
M1R -> GALPHAQ
M1R -> GALPHAQ
M1R -> GALPHAQ
PAFR -> GBETAGAMMA
PAFR -> GBETAGAMMA
PAFR -> GBETAGAMMA
ACH -> M1R
ACH -> M1R
M2R -> GALPHAO
M2R -> GALPHAO
M1R -> GALPHA11
GALPHA13 -> PYK2
FIVEHT1AR -> GALPHAS
FIVEHT1AR -> GBETAGAMMA
PDK1 -> RSK
GRB2 -> SAM68
FIVEHT4R -> GALPHAS
FIVEHT2AR -> GBETAGAMMA
FIVEHT4R -> GBETAGAMMA
SEROTONIN -> FIVEHT4R
SEROTONIN -> FIVEHT2AR
SRC -> SAM68
SRC -> SAM68
SRC -> SAM68
DOPAMINE -> D1R
DOPAMINE -> D1R
DOPAMINE -> D2R
DOPAMINE -> D2R
DOPAMINE -> D2R
D2R -> GALPHAI
D1R -> GALPHAS
D2R -> GBETAGAMMA
PKA -| PLCGAMMA
PLCGAMMA -> DAG
PLCGAMMA -> IP3
PLCGAMMA -> IP3
PLCGAMMA -> IP3
PLCGAMMA -> IP3
PLCBETA -> IP3
PLCBETA -> IP3
PLCBETA -> DAG
PLCBETA -> DAG
PLCBETA -> IP3
PLCBETA -> DAG
PLCBETA -> IP3
GLUTAMATE -> MGLUR1
GLUTAMATE -> MGLUR1
MGLUR1 -> GALPHA11
MGLUR1 -> GALPHAQ
MGLUR1 -> GBETAGAMMA
SHP1 -| RET
GDNF -> RET
RET -> GRB2
PKA -> NFKB
MAPK -> CBP
CALCINEURIN -> NFAT
CALCINEURIN -> NFAT
APAF1 -> CASPASE9
BAP31 -| CASPASE8
BAP31 -> BCL2
BAP31 -> BCLXL
CASPASE8 -> CASPASE3
CASPASE8 -> BID
FADD -> CASPASE8
FAS -> FADD
BID -> CYTOCHROMEC
FASL -> FAS
FASL -> FAS
FASL -> FAS
BAX -> CYTOCHROMEC
PHAP -> APAF1
CALCIUM -> CALNEXIN
SRC -> SHC
SRC -> SHC
PYK2 -> SRC
CALCIUM -> CALRETICULIN
SEC63P -> BIP
PIP2 -> ARNO
PIP2 -> ARNO
PIP3 -> ARNO
FOUREBP1 -> EIF4E
FOUREBP1 -> EIF4E
MTOR -| PHAS
TRKB -> FYN
BDNF -> TRKB
FYN -> NMDAR
FYN -> NMDAR
SRC -> NMDAR
CALPAIN -| NMDAR
FYN -> BETACATENIN
FER -> BETACATENIN
D2R -> GALPHAO
D2R -> GALPHAI
LIMK -| COFILIN
LIMK -| COFILIN
PAK -> RAF1
PAK -> COOL
COOL -> RHO
COOL -> RAC
COOL -> CDC42
RHO -> ROCK
P1433 -| COFILIN
PAK -> LIMK
ROCK -> LIMK
LIMK -| COFILIN
IP3 -> IP3R
IP3 -> IP3R
IP3 -> IP3R
PKA -| IP3R
PKA -| IP3R
IP3 -> IP3R
CAMKII -> AMPAR
PKC -| NOS
CAMKII -| NOS
CAMKII -| NOS
CAMKIV -| NOS
PKA -| NOS
CALMODULIN -> MLCK
CALMODULIN -> MLCK
MLCK -> MYOSIN
MLCK -> MYOSIN
MLCK -> MYOSIN
EEF2K -| EEF2
EEF2K -| EEF2
EEF2K -| EEF2
EEF2K -| EEF2
EEF2K -| EEF2
CALMODULIN -> EEF2K
CALMODULIN -> EEF2K
RSK -| EEF2K
S6K -| EEF2K
MTOR -> S6K
MAPK -> RSK
L1 -> EZRIN
THC -> CB1R
THC -> CB1R
CB1R -> GBETAGAMMA
FAK -> FYN
FAK -> SRC
RABPHILIN -> RAB3
RABPHILIN -> RAB3
CALCIUM -> RABPHILIN
PIP2 -> RABPHILIN
PKA -> RABPHILIN
PKA -> RABPHILIN
CAMKII -> RABPHILIN
CAMKII -> RABPHILIN
PROFILIN -> ACTIN
PROFILIN -> ACTIN
SRC -> CAS
CRK -> C3G
C3G -> RAP1
C3G -> RAP1
RAP1 -> bRAF
RAP1 -> bRAF
PAK -> ABL
NCK -> ABL
IRS1 -> GRB2
ADENOSINE -> A1R
A1R -> GALPHAI
A1R -> GALPHAI
A1R -> GALPHAI
A1R -> GBETAGAMMA
ABL -> VAV
VAV -> RAC
ALPHA1AR -> GBETAGAMMA
ALPHA2AR -> GBETAGAMMA
ALPHA1AR -> GALPHAQ
ALPHA1AR -> GALPHA11
ALPHA2AR -> GALPHAI
ALPHA2AR -> GALPHAO
PKC -> ABL
ABL -> P53
MEK2 -> MAPK
bRAF -> MEK1
bRAF -> MEK1
bRAF -> MEK1
bRAF -> MEK1
bRAF -> MEK1
P1433 -> bRAF
P1433 -> bRAF
P1433 -> bRAF
RAP1 -| RAF1
RAP1 -| RAF1
PKB -| RAF1
RAS -> RAF1
RAS -> RAF1
CALCINEURIN -> NOS
PKA -| RAF1
PKA -| RAF1
PKC -> RAF1
LCK -> RAF1
PKA -| RAP1
RAP1 -| RAF1
RAS -> RAF1
PKA -| CAMKK
CAMKK -> CAMKI
CALMODULIN -> CAMKK
pGC -> CGMP
pGC -> CGMP
CGMP -> PKG
CGMP -> PKG
CGMP -> PKG
SPINOPHILIN -> PP1
CAMKII -> CREB
CAMKI -> CREB
CAMKII -| SPINOPHILIN
PKA -> SPINOPHILIN
SPINOPHILIN -> PP1
MP1 -> MEK1
MP1 -> MAPK
JIP -| JNK
JIP -| JNK
NIK -> MEKK1
NIK -> NCK
JIP -> MLK3
JIP -> MEK7
JIP -> DLK
MEKK3 -> MEK3
MEKK2 -> MEK4
MEKK4 -> MEK3
MEKK4 -> MEK6
PKC -> CPI17
PKC -> CPI17
CPI17 -| MYOSINPPASE
PKN -> CPI17
ILK -> CPI17
ROCK -> CPI17
VDAC2 -| BAK
BCLXL -| BAX
JNK -> BIM
BCL2 -| BAX
BIM -> BAX
BIM -| BCL2
JNK -> ELK1
JNK -> ELK1
P38 -> ATF2
MEK3 -> P38
MEK6 -> P38
P38 -> ELK1
P38 -> MEF2
ARH2 -> RAC
ARH2 -> RHO
JIP -> MEK4
MEK7 -> JNK
BETAARRESTIN -> FRIZZLED
CASK -> DISHEVELED
CASK -> DISHEVELED
CASK -> DISHEVELED
DISHEVELED -> PAR1
BETAARRESTIN -> SRC
SRC -> SAM68
SRC -> SAM68
PDZGEF -> RAP1
PDZGEF -> RAP2
CALMODULIN -| RAB3
CALCIUM -> SYNAPTOTAGMIN
CALCIUM -> DYNAMIN
PKC -| DYNAMIN
PKC -| MARCKS
PKC -| MARCKS
PKC -> GAP43
PKC -> GAP43
RABGDI -| RAB3
PKC -> AC2
PKC -> AC2
PKC -> AC2
PKC -> AC2
PKC -> AC2
GALPHAS -> AC1
GALPHAS -> AC1
GALPHAS -> AC1
AC5 -> CAMP
PKC -> AC5
GALPHAS -> AC5
NO -> pGC
NO -> pGC
GALPHAS -> AC2
GALPHAS -> AC2
AC1 -> CAMP
AC2 -> CAMP
BETA2AR -> GALPHAS
BETA2AR -> GBETAGAMMA
SEROTONIN -> FIVEHT1CR
SEROTONIN -> FIVEHT1CR
RHEB -> RAF1
PKA -| RAF1
RAS -> RAF1
EGFR -> GRB2
PYK2 -> GRB2
PYK2 -> GRB2
PYK2 -> SRC
PYK2 -| KV12
PYK2 -| KV12
KV12 -> POTASSIUM
SYNTAXIN -> KV11
GBETAGAMMA -> KV11
KV11 -> POTASSIUM
SYNTAXIN -| NTYPECA
SYNTAXIN -| NTYPECA
GBETAGAMMA -> SYNTAXIN
SYNAPTOTAGMIN -> LTYPECA
SYNAPTOTAGMIN -> RTYPECA
RTYPECA -> CALCIUM
CALMODULIN -> MUNC13
CALMODULIN -> MUNC13
CASK -> TBR1
CASK -> PMCA
SHIP2 -> GRB2
PDGFR -> SHIP2
PDGFR -> SHIP2
PDGFR -> APS
PDGF -> PDGFR
RYR -> CALCIUM
SHIP2 -| GAB1
SHIP2 -| SPROUTY
SHIP2 -| PAXILLIN
CSK -> PAXILLIN
CSK -> FAK
CSK -| SRC
CSK -| SRC
SHIP2 -> GRB2
SHIP2 -> PI3K
CALMODULIN -| NMDAR
SEROTONIN -> FIVEHT1AR
SEROTONIN -> FIVEHT1AR
SEROTONIN -> FIVEHT1AR
SEROTONIN -> FIVEHT2AR
SEROTONIN -> FIVEHT2AR
SEROTONIN -> FIVEHT4R
ADENOSINE -> A1R
ADENOSINE -> A1R
ADENOSINE -> A2AR
ADENOSINE -> A2AR
A2AR -> GALPHAS
A2AR -> GALPHAS
A2AR -> GBETAGAMMA
VAV -> RHO
VAV -> RHO
VAV -> RHO
VAV -> CDC42
VAV -> CDC42
RHOGEF -> RHO
GALPHA12 -> RHOGEF
GALPHA13 -> RHOGEF
PIP3 -> VAV
ARNO -> ARF
EFA6 -> ARF
BDNF -> TRKB
RAP1 -> bRAF
RAS -> bRAF
PKA -> bRAF
D1R -> GBETAGAMMA
M1R -> GBETAGAMMA
RAP1 -> RALGDS
PKC -> PLA2
MAPK -> PLA2
P38 -> PLA2
RHO -> CITRON
PKG -> NOS
ELK1 -> SRE
FAK -| ALPHAACTININ
BRADYKININ -> BR1R
BRADYKININ -> BR1R
BR1R -> GBETAGAMMA
BRADYKININ -> BR1R
PYK2 -> SRC
BR1R -> GALPHAQ
BR1R -> GBETAGAMMA
BR1R -> GALPHAI
BR1R -> GALPHA11
BR1R -> GALPHAQ
DAG -> RASGRP
CALCIUM -> RASGRP
RASGRF -> RAS
RASGRF -> RAC
CAMKII -> RASGRF
CALMODULIN -| IP3R
RASGRP -> RAS
PKC -> RASGRP
RASGRF -> RAS
RASGRF -> RAS
MKP5 -| P38
MKP5 -| JNK
RASGRF -> RAS
CALCIUM -> CAPRI
CALCIUM -> CAPRI
CAPRI -| RAS
CAPRI -| RAS
RASGRF -> RAS
RASGRF -> RAS
RASGRF -> RAC
CALMODULIN -> RASGRF
CALMODULIN -> RASGRF
CAMP -> EPAC
CAMP -> EPAC
EPAC -> RAP1
CALMODULIN -> RIN1
RIN1 -| RAS
P1433 -| RIN1
RIN1 -| RAS
PKD -> P1433
GLYCINE -> GLYR
PKA -> GLYR
PKC -| GLYR
SRC -> GLYR
SRC -> GABAAR
BID -> BAX
TRKB -> SHC
EGFR -> SHC
GSK3 -> CREB
PKB -| GSK3
PP2A -> GSK3
SHP1 -> JAK
GALPHA13 -> RADIXIN
PKA -| RAP1
PAFR -> GALPHAI
CAMKIV -> CREM
CAMKIV -> CREM
ANP -> pGC
NWASP -> ARP23
ARP23 -> ACTIN
IKBB -| NFKB
IGF1 -> IGF1R
PKG -> ADPRIBSYCYCLASE
M1R -> GALPHA11
RGS2 -| GALPHA11
RGS2 -| GALPHAQ
M1R -> GBETAGAMMA
RGS2 -| GALPHAI
RGS2 -| GALPHAQ
EGF -> EGFR
MAPK -> KV42
MAPK -> KV42
KV42 -> POTASSIUM
IGF1R -> VAV
KV42 -> POTASSIUM
P38 -> STAT
AXIN -> GSK3
AXIN -| BETACATENIN
AXIN -> GSK3
AXIN -| BETACATENIN
GSK3 -| BETACATENIN
APC -| BETACATENIN
AXIN -> GSK3
AXIN -| BETACATENIN
GSK3 -> APC
GSK3 -| BETACATENIN
AXIN -> GSK3
AXIN -| BETACATENIN
GSK3 -> APC
APC -| BETACATENIN
AXIN -> MEKK1
AXIN -> MEKK1
AXIN -> MEKK4
DISHEVELED -| AXIN
DISHEVELED -| AXIN
PLCBETA -| PIP2
GALPHAI -| AC2
CREM -| CREB
GRB2 -> DYNAMIN
PIP2 -> DYNAMIN
PIP2 -> DYNAMIN
GRB2 -> DYNAMIN
GRB2 -> DYNAMIN
SRC -> DYNAMIN
TUBULIN -> DYNAMIN
PIP2 -> DYNAMIN
JIP -> RASGRF
SRC -> RASGRF
JIP -> TIAM1
P38 -> ATF2
JIP -> P38
ALPHA7NACHR -> SODIUM
ALPHA7NACHR -> SODIUM
ACH -> ALPHA7NACHR
ACH -> ALPHA7NACHR
ARFGEF -> ARF
ARFGEF -> ARF
PKA -> CBP
NFKB -> CBP
PKG -> CREB
CREB -> CBP
CREB -> CBP
CREB -> CBP
CBP -> PCAF
CREB -> TFIID
CREB -> TFIID
PKA -> DARPP32
PKA -> DARPP32
PKA -> DARPP32
CBP -| TCF
CBP -> BETACATENIN
CARM1 -> BETACATENIN
FIBRONECTIN -> INTEGRIN
DARPP32 -| PP1
DARPP32 -| PP1
SPAL -| RAP1
PKA -| BETA2AR
ARFGAP -| ARF
RAP1GAP -| RAP1
P1433 -> bRAF
RGS4 -| GALPHAQ
GAIP -| GALPHAQ
MYOSINPPASE -| MYOSIN
MKP1 -| P38
MKP1 -| MAPK
MKP1 -| MAPK
MKP1 -| JNK
DISHEVELED -| AXIN
FAK -> SHC
PTEN -| FAK
PAR2 -> GBETAGAMMA
PAR2 -> GBETAGAMMA
PAR2 -> GBETAGAMMA
PAR2 -> GALPHAQ
TRYPSIN -> PAR2
BETAARRESTIN -| PAR2
PYK2 -> EGFR
PYK2 -> SRC
PKC -| FASCIN
SHC -> SOS
ABL -> CDK5
TRKA -> GRB2
MEK2 -> PRK2
GBETAGAMMA -| AC1
CALCIUM -| AC5
GALPHAI -| AC5
TUBERIN -| RAP1
SYNAPSIN -| GALPHAZ
PKA -| SYNAPSIN
PAK -| SYNAPSIN
D2R -> GALPHAZ
D2R -> GALPHAI
FIVEHT1AR -> GALPHAZ
GALPHAZ -| AC5
GALPHAZ -| AC1
IKBA -| NFKB
CBL -| VAV
CREM -| DREAM
CALCINEURIN -| DARPP32
PKA -| D1R
SIAH -| VAV
DOK -> RASGAP
DOK -> RASGAP
ABL -> DOK
ABL -> DOK
EPHB2 -> DOK
EPHB2 -> RASGAP
EPHRIN -> EPHB2
BETAARRESTIN -| BETA2AR
WNT -> FRIZZLED
WNT -> FRIZZLED
WNT -> LRP
GABAAR -> CHLORIDE
NE -> ALPHA1AR
NE -> ALPHA2AR
NE -> BETA2AR
NE -> ALPHA1AR
NE -> ALPHA2AR
NE -> BETA2AR
NE -> BETA2AR
CBL -| SRC
CBL -| PI3K
CBL -| SHC
CBL -| EGFR
CBL -| GRB2
IRS1 -> GRB2
KV41 -> Potassium
KV41 -> Potassium
CAMKII -> KV42
DREAM -| KV42
DREAM -| KV42
PKA -| KV42
DREAM -| KV41
KV14 -> Potassium
SNAP25 -| NTYPECA
SYNTAXIN -| NTYPECA
PKA -> TAU
CASK -> TAU
PKA -> TAU
CALPAIN -| TAU
MAPK -> TAU
MAPK -> TAU
GRB2 -> GAB1
GAB1 -> PI3K
M4R -> EEF1A2
ACH -> M4R
M4R -> GALPHAI
M4R -> GBETAGAMMA
CALMODULIN -> PLCBETA
M4R -> GALPHAI
GLUTAMATE -> KAR
PKA -> KAR
PKC -> KAR
CALCINEURIN -> GABAAR
PKA -> AMPAR
GBETAGAMMA -> PQCaCh
PKC -> NTYPECA
PKC -> NTYPECA
CAMKII -> NTYPECA
SYNTAXIN -| NTYPECA
SNAP25 -| NTYPECA
SNAP25 -| NTYPECA
PKC -| AMPAR
CALMODULIN -| IP3R
GLUTAMATE -> AMPAR
AMPAR -> SODIUM
CAMKII -> RYR
CALCIUM -| ALPHAACTININ
CALMODULIN -| NMDAR
CALMODULIN -| NMDAR
SYNTAPHILIN -| SYNTAXIN
GAT1 -| GABA
GAT1 -| GABA
SAP97 -| KAR
HOMER -> RYR
MLK3 -> MEK4
PAK -> LIMK
ROCK -> LIMK
CALMODULIN -> DAPK
SMACDIABLO -| XIAP
XIAP -| CASPASE3
XIAP -| CASPASE7
XIAP -| CASPASE9
XIAP -| CASPASE3
XIAP -| CASPASE7
XIAP -| CASPASE9
cIAP1 -| CASPASE3
cIAP1 -| CASPASE7
cIAP2 -| CASPASE3
cIAP2 -| CASPASE7
XIAP -| CASPASE3
XIAP -| CASPASE7
CYTOCHROMEC -> APAF1
CYTOCHROMEC -> APAF1
APAF1 -> CASPASE9
APAF1 -> CASPASE9
APAF1 -> CASPASE9
dATP -> APAF1
dATP -> APAF1
NAIP -| CASPASE9
CALCIUM -> HIPPOCALCIN
CALCIUM -> HIPPOCALCIN
HIPPOCALCIN -> NAIP
HIPPOCALCIN -> NAIP
NAIP -| CASPASE3
NAIP -| CASPASE7
APOLLON -| SMACDIABLO
APOLLON -| CASPASE9
SURVIVIN -| SMACDIABLO
PKA -> MAP2
PKA -> MAP2
PKC -> MAP2
CAMKII -> MAP2
PKC -> MBP
SYK -> TUBULIN
ZAP70 -> TUBULIN
FYN -> TUBULIN
LYN -> TUBULIN
SRC -| CORTACTIN
CORTACTIN -> ARP23
CORTACTIN -> ACTIN
CORTACTIN -> ACTIN
CALMODULIN -| MARCKS
CALMODULIN -| MARCKS
PKC -| MARCKS
CDK5 -> NFH
PP2A -| NFH
PP1 -> COFILIN
PP2A -> COFILIN
COFILIN -| ACTIN
COFILIN -| ACTIN
GELSOLIN -| ACTIN
PROFILIN -> PIP2
PROFILIN -> PIP2
PROFILIN -> PIP2
CASPASE6 -| LAMINA
CASPASE3 -| GELSOLIN
PIP2 -> GELSOLIN
GELSOLIN -| CASPASE9
CALCINEURIN -| MAP2
CALCINEURIN -| MAP2
CALCINEURIN -| TAU
CALCINEURIN -| TUBULIN
MAPK -| NFH
MAPK -| NFM
CALPAIN -| SPECTRIN
PKC -| ADDUCIN
CALMODULIN -> ADDUCIN
PKC -| ADDUCIN
CALMODULIN -> ADDUCIN
PKA -| ADDUCIN
CALMODULIN -| SPECTRIN
EGFR -> N41
SYNAPSIN -> ACTIN
CAMKII -| SYNAPSIN
PKA -| SYNAPSIN
CASK -| ANKYRIN
ROCK -> PROFILIN
PKA -> FILAMIN
PKA -> FILAMIN
PAK -> COOL
PAK -> COOL
SHANK -> COOL
CALPAIN -| MAP2
PKA -> MAP2
MYOSINV -> CAMKII
CRMP2 -> TUBULIN
PKC -> EIF4E
PKC -> EIF4E
RSK -> S6
S6 -> S40
SRP54 -> NASCENTCHAIN
SRP54 -> NASCENTCHAIN
SRP54 -> SRPR
SRPR -> SEC61P
S60 -> SRP54
PERK -> EIF2
PKR -| EIF2
PKR -| EIF2
S6K -> S6
CASPASE3 -| EIF4G
PKR -| EIF2
PKR -| EIF2
EIF5 -> EIF2
DCP1 -| mRNA
DCP1 -| mRNA
PDI -> NASCENTCHAIN
PHAS -| EIF4E
EIF3 -> EIF4G
PP2A -> GSK3
PP2A -| PKB
CALCINEURIN -| TAU
CALCINEURIN -| TAU
SIVA1 -| BCLXL
CALBRAIN -| CAMKII
CALMODULIN -| AKAP
CALMODULIN -| RAS
CALMODULIN -| VAMP
PKC -| bARK
CALMODULIN -| bARK
GRB2 -| PTPA
GABABR -> GALPHAO
GABABR -> GBETAGAMMA
PKC -> MGLUR1
PDE1A -| cGMP
PDE1A -| cGMP
PDE1A -| cGMP
CALMODULIN -> PDE1A
PDE1B -| cGMP
PDE1B -| cGMP
PDE1B -| cGMP
CALMODULIN -> PDE1B
PDE1C -| cGMP
CALMODULIN -> PDE1C
PDE2A -| CAMP
cGMP -> PDE2A
cGMP -| PDE3A
cGMP -| PDE3B
PDE3A -| CAMP
PDE3B -| CAMP
PKA -> PDE3A
PKA -> PDE3B
PDE4A -| CAMP
PDE4A -| CAMP
PDE4B -| CAMP
PDE4B -| CAMP
PDE4C -| CAMP
PDE4D -| CAMP
PKA -> PDE4D
PKG -> PDE5A
PKA -> PDE5A
PDE5A -| cGMP
BETAARRESTIN -> PDE4D
BETAARRESTIN -> PDE4D
PKA -> NMDAR
PKC -| NMDAR
GALPHA11 -> PLCBETA
PA -> PLCBETA
CBL -| CRK
CBL -| CRK
CBL -| GRB2
CBL -| FYN
CBL -| FYN
CBL -| LCK
CBL -| LCK
CDC42 -> MLK3
RAC -> MLK3
JNK -> ATF2
SYNGAP -| RAS
SYNGAP -| RAS
SYNGAP -| RAP1
CAMKII -> ASK1
ASK1 -> MEK3
ASK1 -> MEK4
MEKK3 -> MEK3
MEKK2 -> MEK4
MUPP1 -| SYNGAP
CAMKII -| SYNGAP
RASGAP -| RAS
RASGAP -> PKB
ILK -> PKB
ILK -| GSK3
CAMKK -> CAMKI
CAMKK -> CAMKIV
CAMKK -> CAMKI
CAMKK -> CAMKIV
CAMKK -> PKB
CAMKIV -> CREB
CAMKII -> CREB
CAMKK -> CAMKI
CAMKIV -> SYNAPSIN
CHOLESTEROL -> SYNAPTOPHYSIN
MUNC13 -> SYNTAXIN
SNAPIN -> AC5
SNAPIN -| SNAP25
CASK -> SYNTAXIN
PKA -> SNAPIN
PKI -| PKA
DYRK -| EIF2
DYRK -| TAU
PP2A -| CAS
GSK3 -> INHIBITOR2
CASK -> INHIBITOR2
GSK3 -> INHIBITOR2
INHIBITOR2 -| PP1
SHP1 -| ALPHAACTININ
SHP1 -| SPROUTY
PTP1B -| IR
PP5 -| TAU
CAMKPASE -| CaMKI
CAMKPASE -| CaMKI
CAMKPASE -| CAMKII
CAMKPASE -| CAMKIV
PP1 -| NMDAR
PP2A -| NMDAR
CALMODULIN -| NMDAR
PP1 -| CAMKII
PP1 -| CAMKII
PKA -| I1
I1 -| PP1
I1 -| PP1
CALCINEURIN -| SYNAPSIN
PKC -| GSK3
PKC -| GSK3
PTPA -> FYN
PTPA -> FYN
PTPA -> SRC
PTPA -> LCK
PKC -| SNAP25
PKC -| SNAP25
CDK5 -| MUNC18
CDK5 -| MUNC18
PKC -| MUNC18
CAMKII -| SYNTAXIN
CASPASE3 -| PIP5K
PIP2 -> GELSOLIN
PIP2 -| CASPASE3
PIP2 -| CASPASE8
PIP2 -| CASPASE9
KSR -> RAF1
bARK -| MOR
bARK -| MOR
BETAARRESTIN -| MOR
CALCIUM -| SV2A
PKC -| BCL2
GSK3 -| CJUN
GSK3 -| TAU
RAF1 -| BAD
BAD -> BCLXL
PKA -| BAD
PP2C -> BAD
PP2A -> BAD
PP1 -> BCL2
PKB -| CASPASE9
SAM68 -| CBP
DREAM -| DRE
CALCIUM -> SYNAPTOTAGMIN
SYNAPTOTAGMIN -> SYNTAXIN
RAL -> RALBP1
REELIN -| INTEGRIN
REELIN -| INTEGRIN
PKC -| PMCA
PKC -| PMCA
PKA -| PMCA
PKA -| STEP
CALCINEURIN -> STEP
STEP -| MAPK
CASPASE7 -| MEF2
CASPASE3 -| MEF2
SRC -> SPECTRIN
CALPAIN -| SPECTRIN
FYN -> AMPAR
CALPAIN -| AMPAR
SRC -> NMDAR
CALPAIN -| NMDAR
PKC -| LTYPECA
PKA -| LTYPECA
PKA -| LTYPECA
PP2A -> LTYPECA
PKA -| LTYPECA
CASPASE3 -| PARP
PKC -| IRS1
CAMKII -| RICS
RACK -| FYN
NAKED -| FRIZZLED
INHIBITOR2 -| PP1
INHIBITOR2 -| PP1
PP2A -| CREB
PKC -| GABAAR
PKC -| PLCBETA
PKA -| PLCBETA
PKC -| PLCBETA
PKC -| PLCBETA
PKA -| PLCBETA
PKC -| DGK
PKC -| DGK
PKB -| FORKHEAD
PKB -| FORKHEAD
PKB -| P53
PKB -| BAD
PKB -| BAD
BAD -> BCL2
BAD -> BCL2
BAX -| BAD
BAK -| BAD
PP2A -| CAMKIV
PP2A -| CAMKIV
PAK -| MLCK
GSK3 -| NFAT
CASK -| NFAT
P38 -| NFAT
P38 -| NFAT
PKA -| NFAT
P1433 -| NFAT
P1433 -| FORKHEAD
FLIP -| CASPASE8
RET -> RAI
FAK -> FYN
CRK -> C3G
MEKK1 -> JNK
PIN1 -> CJUN
SV2A -> SYNAPTOTAGMIN
CALCIUM -> SYNAPTOTAGMIN
SYNAPTOTAGMIN -> SYNTAXIN
CAMP -> CAMPGEFII
PIP2 -> NWASP
PIP2 -> NWASP
PIP2 -> NWASP
CDC42 -> NWASP
CDC42 -> NWASP
CDC42 -> NWASP
GRB2 -> NWASP
EGFR -> NWASP
PP2A -| BCL2
RSK -| BAD
PKA -| BAD
PKB -| BAD
CASPASE3 -| PP2A
CASPASE3 -> CALCINEURIN
CASPASE3 -> CALCINEURIN
SRC -> PLCGAMMA
SRC -> PLCGAMMA
LCK -> PLCGAMMA
LYN -> PLCGAMMA
FYN -> PLCGAMMA
HCK -> PLCGAMMA
ROCK -> CRMP2
LARG -> RHO
SODIUM -> GAT1
CJUN -> CREB
CJUN -> ATF1
CFOS -> ATF1
MEKK1 -> SEK
P38 -> AP1
CAMKII -> SAP97
GSK3 -| TAU
PDK1 -> PKC
PP2A -| CAMKI
CAMKII -| PP2A
SRC -> DYNAMIN
LRP -> FRIZZLED
BCL2 -| BID
BCLXL -| BID
BCL2 -| BIK
BCLXL -| BIK
CASPASE8 -> BID
PIP3 -> ILK
PTEN -| PIP3
GRIT -| RHO
GRIT -| CDC42
GRIT -| RAC
CASPASE3 -| DNAPK
P1433 -| RAF1
CALCINEURIN -| I1
CASPASE3 -| RB
CALCINEURIN -| CAMKIV
DAPK -| SYNTAXIN
CASPASE8 -| PKR
CASPASE3 -| PKR
CASPASE7 -| PKR
CALCINEURIN -| NMDAR
CALCINEURIN -| DARPP32
AMISYN -| SYNTAXIN
AMISYN -| SNAP25
CALMODULIN -> RYR
ADPRIBSYCYCLASE -> cADPR
ADPRIBSYCYCLASE -> cADPR
cADPR -> RYR
ANANDAMIDE -> CB1R
ANANDAMIDE -> CB2R
CB1R -> GALPHAI
CB1R -> GALPHAO
CB1R -> GBETAGAMMA
CB2R -> GALPHAI
CB2R -> GALPHAO
CB2R -> GBETAGAMMA
CALCINEURIN -> IP3R
FKBP -> CALCINEURIN
FKBP -> CALCINEURIN
FKBP -> CALCINEURIN
FKBP -> CALCINEURIN
GLUTAMATE -> MGLUR7
MGLUR7 -> GALPHAI
MGLUR7 -> GALPHAO
MGLUR7 -> GBETAGAMMA
CALMODULIN -| MGLUR7
PKC -> MGLUR7
PKC -> MGLUR7
PKA -> MGLUR7
PKG -> MGLUR7
CALMODULIN -| MGLUR7
MGLUR7 -> GBETAGAMMA
CALMODULIN -| D2R
PKC -> MGLUR7
PICK1 -| MGLUR7
GSK3 -| PRESENILIN
GSK3 -| TAU
AXIN -> GSK3
GSK3 -| PRESENILIN
GSK3 -| TAU
CALCIUM -> SORCIN
SORCIN -| RYR
SORCIN -| RYR
DOC2 -> MUNC13
CALCIUM -> DOC2
DOC2 -> MUNC13
KIR41 -> POTASSIUM
PSD95 -> MAP1A
MLK -> PSD95
SRC -> bARK
SRC -> MUSK
CALMODULIN -> RIC
CALMODULIN -> RIC
CALMODULIN -> RIN
CALMODULIN -> RIN
CALMODULIN -> RIN
N41 -> AMPAR
CALCINEURIN -| LTYPECA
IP3R -> CALCIUM
IP3R -> CALCIUM
PQCaCh -> CALCIUM
PQCaCh -> CALCIUM
LTYPECA -> CALCIUM
LTYPECA -> CALCIUM
NTYPECA -> CALCIUM
NTYPECA -> CALCIUM
SRC -> SYK
SYK -> PLCGAMMA
SYK -> PLCGAMMA
NEUROFIBROMIN -| RAS
NEUROFIBROMIN -| RAS
DOPAMINE -> D3R
D3R -> GALPHAI
D3R -> GALPHAO
D3R -> GBETAGAMMA
D3R -> GRB2
CAMKII -> SYNAPTOTAGMIN
MAPK -> SAM68
SRC -> LTYPECA
FYN -> LTYPECA
PKA -| KIR23
KIR21 -> POTASSIUM
KIR23 -> POTASSIUM
FYN -> NMDAR
NRG -> ERBB
PKA -| LTYPECA
SEC63P -> SEC61P
PIP2 -> RYR
SYNTAXIN -| NTYPECA
PKA -| PQCaCh
BIP -> SEC61P
BAG1 -> RAF1
BAG1 -> RAF1
BAG1 -> RAF1
BAG1 -> BCL2
BAG1 -> BCL2
MDM2 -| P53
PIP3 -> PKC
GKAP -> NOS
CALCIUM -> VILIP
CALCIUM -> VILIP
CALCIUM -> NCS1
PKC -> RAF1
PKC -> RAF1
CALPAIN -| NMDAR
PKA -> MST3
CREB -> CBP
EGFR -> SHC
INTEGRIN -> PYK2
INTEGRIN -> PYK2
CALCINEURIN -> BAD
P1433 -> P53
CDK5 -> TAU
CDK5 -> TAU
IR -> IRS2
IR -> IRS2
IR -> IRS2
TRKB -> IRS2
IRS2 -> PI3K
IRS1 -> PI3K
TRKB -> IRS1
P1433 -| IRS1
MAPK -> MEF2
MAPK -> MEF2
CALPAIN -| CAIN
CAIN -| CALCINEURIN
MAPK -> MARCKS
CALCIUM -> DREAM
DGK -| DAG
PLCGAMMA -| PIP2
EGFR -> PLCGAMMA
PDGFR -> PLCGAMMA
PKA -| GABAAR
PKA -| GABAAR
PKA -| GABAAR
CALCINEURIN -| CREB
CSP -| NTYPECA
CSP -> GBETAGAMMA
GBETAGAMMA -| NTYPECA
SYNTAXIN -| NTYPECA
CREB -> TFIIB
SHC -> PI3K
ERBB -> SHC
ERBB -> PI3K
TRKA -> PI3K
PKA -> RIM
ADAPTIN -| GABAAR
ADAPTIN -> CLATHRIN
ADAPTIN -> CLATHRIN
ADAPTIN -> DYNAMIN
ADAPTIN -> DYNAMIN
RHO -> PIP5K
PIP5K -> PIP2
CERAMIDE -> PP2A
CERAMIDE -> PP1
PA -| PP1
CERAMIDE -> PP2A
PRMT1 -> SAM68
GRAB -> RAB3
COLLAGEN -> INTEGRIN
VITRONECTIN -> INTEGRIN
FIBRINOGEN -> INTEGRIN
C3G -> RAS
ENKEPHALIN -> DOPR
ENKEPHALIN -> KOPR
ENKEPHALIN -> MOPR
ENKEPHALIN -> NOPR
DOPR -> GBETAGAMMA
KOPR -> GBETAGAMMA
MOPR -> GBETAGAMMA
NOPR -> GBETAGAMMA
DOPR -> GALPHAO
DOPR -> GALPHAI
KOPR -> GALPHAO
KOPR -> GALPHAI
MOPR -> GALPHAO
MOPR -> GALPHAI
NOPR -> GALPHAO
NOPR -> GALPHAI
ERBB -> SYNTROPHIN
NMDAR -> PLCGAMMA
NT4 -> TRKB
NT4 -> TRKB
NT4 -> TRKB
CAMKII -> SAP97
NMDAR -> SAP102
TRKA -> IRS1
TRKA -> SHC
RAP2 -> RAS
RAP2 -> RALGDS
IGF1R -> IRS1
IGF1R -> SHC
IGF1R -> GRB10
FAK -| ALPHAACTININ
IR -> GRB10
GRB10 -> PI3K
CALCINEURIN -> GABAAR
RALBP1 -| CDC42
RAL -> RALBP1
RALBP1 -| RAC
CALCINEURIN -| CREB
PP1 -| CREB
PP2A -| CREB
CEK1 -> RAF1
CERAMIDE -> CEK1
CERAMIDE -> PKC
CERAMIDE -> PKC
MGLUR1 -> TAMALIN
MGLUR1 -> TAMALIN
TAMALIN -> SYK
SRCASM -> FYN
GRB2 -> SRCASM
CytochromeC -> IP3R