### Fri Jun 04 11:38:31 AM BID -> Caspase PDGF -> PDGFR S1P -> PDGFR IL2RB -> FYN TCR -> FYN IL2RBT -> IL2RB GRB2 -> PLCG1 PLCG1 -> RAS GAP -| RAS IL15 -| GAP IL2 -| GAP TBET -| IL2 RAS -> MEK MEK -> ERK RAS -> PI3K TNF -> TPL2 TPL2 -> NFKB TRADD -> NFKB DISC -| FLIP IAP -| TRADD A20 -| TRADD BID -| IAP FYN -> Cytosig CD45 -> LCK ZAP70 -| LCK FYN -| ZAP70 LCK -> ZAP70 ZAP70 -> GRB2 PI3K -> NFAT NFKB -> RANTES JAK -> STAT3 JAK -> TBET TBET -> IL2RBT STAT3 -> IL2RAT IL2RAT -> IL2RA RANTES -> JAK IL2RA -> JAK SOCS -| JAK IFNGT -> IFNG SMAD -| IFNG P2 -| IFNG Caspase -> Apoptosis Apoptosis -> Apoptosis CTLA4 -| TCR Stimuli -> TCR TCR -> CTLA4 Ceramide -| S1P SPHK1 -> S1P JAK -> SOCS STAT3 -> P27 P27 -| Prolif IFNG -> CREB TBET -> IFNGT GPCR -> SMAD IFNG -> P2 CREB -> GZMB NFKB -> TNF NFKB -> A20 ERK -> FasL NFAT -> FasL NFKB -> FasT FasL -> Fas sFas -| Fas FasT -> sFas Fas -> Ceramide FLIP -| DISC Ceramide -> DISC Caspase -> BID GZMB -> BID BclxL -| BID MCL1 -| BID DISC -| BclxL STAT3 -> MCL1 S1P -> GPCR PDGFR -> SPHK1