Caspase -> Apoptosis Apoptosis -> Apoptosis TCR -> CTLA4 Stimuli -> TCR CTLA4 -| TCR S1P -> PDGFR PDGF -> PDGFR TCR -> FYN IL2RB -> FYN FYN -> Cytosig CD45 -> LCK TCR -> LCK IL2RB -> LCK ZAP70 -| LCK LCK -> ZAP70 FYN -| ZAP70 IL2RB -> GRB2 ZAP70 -> GRB2 GRB2 -> PLCG1 PDGFR -> PLCG1 GRB2 -> RAS PLCG1 -> RAS GAP -| RAS RAS -> GAP PDGFR -> GAP GAP -> GAP IL15 -| GAP IL2 -| GAP RAS -> MEK MEK -> ERK PI3K -> ERK PDGFR -> PI3K RAS -> PI3K TPL2 -> NFKB PI3K -> NFKB FLIP -> NFKB TRADD -> NFKB IAP -> NFKB PI3K -> NFAT NFKB -> RANTES NFKB -> IL2 STAT3 -> IL2 NFAT -> IL2 TBET -| IL2 ERK -> IL2RBT TBET -> IL2RBT IL2RBT -> IL2RB IL2 -> IL2RB IL15 -> IL2RB IL2 -> IL2RAT STAT3 -> IL2RAT NFKB -> IL2RAT IL2 -> IL2RA IL2RAT -> IL2RA IL2RA-| IL2RA IL2RA -> JAK IL2RB -> JAK RANTES -> JAK IFNG -> JAK SOCS -| JAK #CD45 -| JAK JAK -> SOCS IL2 -| SOCS IL15 -| SOCS JAK -> STAT3 STAT3 -> P27 STAT3 -> Prolif P27 -| Prolif JAK -> TBET TBET -> TBET ERK -> CREB IFNG -> CREB TBET -> IFNGT STAT3 -> IFNGT NFAT -> IFNGT IL2 -> IFNG IL15 -> IFNG Stimuli -> IFNG IFNGT -> IFNG SMAD -| IFNG P2 -| IFNG IFNG -> P2 P2 -> P2 CREB -> GZMB IFNG -> GZMB TBET -> GZMB #TAX -> TPL2 PI3K -> TPL2 TNF -> TPL2 NFKB -> TNF TNF -> TRADD IAP -| TRADD A20 -| TRADD STAT3 -> FasL NFKB -> FasL NFAT -> FasL ERK -> FasL NFKB -> FasT FasT-> Fas FasL -> Fas sFas -| Fas FasT -> sFas S1P -> sFas Fas -> Ceramide S1P -| Ceramide FasT -> DISC Fas -> DISC IL2 -> DISC Ceramide -> DISC FLIP -| DISC TRADD -> Caspase GZMB -> Caspase BID -> Caspase IAP -| Caspase DISC -> Caspase NFKB -> FLIP CREB -> FLIP IFNG -> FLIP DISC -| FLIP NFKB -> A20 Caspase -> BID GZMB -> BID BclxL -| BID MCL1 -| BID NFKB -> IAP BID -| IAP NFKB -> BclxL STAT3 -> BclxL BID -| BclxL GZMB -|BclxL DISC -| BclxL IL2RB -> MCL1 STAT3 -> MCL1 NFKB -> MCL1 PI3K -> MCL1 S1P -> GPCR GPCR -> SMAD PDGFR -> SPHK1 SPHK1 -> S1P Ceramide -| S1P